Sachin Karne was born in Pune in 1965, He has a Diploma in drawing and painting from the Abhinav Kala Mahavidyalaya, Pune in 1987 and a Diploma in art education at the Sir J. J. School of Art, Mumbai in 1988. He also has an Post Diploma from the Faculty of Fine Arts, M. S. University, Baroda, 1990.

Karne has exhibited widely in India, and has had solo exhibitions of his works at Sakshi Gallery, Mumbai, in 2007, 2005, 2003 and 1999; Rijksakademie van Beeldende Kunsten, Amsterdam, in 2003; and Gallery 7, Mumbai, in 1997. His works have also been featured in several group exhibitions at the Sans Tache Gallery, Mumbai, in 2008; the National Gallery of Modern Art, Mumbai and New Delhi, and Victoria Memorial Hall, Kolkata, in 2007; the Guild Gallery, Mumbai in 1998 and 1999. He was awarded a Junior Fellowship by the Human Resource Development Ministry, in 2000-02 and was an artist in residence at the Rijksakademie van Beeldende Kunsten, Amsterdam, in 2002 -03.

He has taugh at the Faculty of Fine Arts in Baroda.

His works deals with the powerful undercurrent that governs a man`s world. In his use of colors and symbols, that serve more like icons, you can imagine a human who refuses to be cowed down by terror. "My curiosity is piqued by the way certain objects are given a certain sanctity, while others remain ignored," he points out. Elements that form a part of daily existence are the same that creep into the corner and crevices of the canvas he paints. He uses colors that are strong and resilient. Elements that form a part of daily existence are the same that creep into the corner and crevices of the canvas he paints.

The artist lives and works in Baroda.